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Anticoagulants: Phenobarbital lowers the plasma levels of dicumarol (title Earlier applied: bishydroxycoumarin) and leads to a decrease in anticoagulant action as measured via the prothrombin time. Barbiturates can induce hepatic microsomal enzymes leading to improved metabolism and decreased anticoagulant response of oral anticoagulants (e.Untimel

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